Mutations in ABCC7

reference sequence

Region Mutation
Publications
Sentences
MutMiner_hits
SNAP2
PROVEAN
Effect_ExpVar
CL0 p.Met    1 Val details homologous mutations 1 1 1 N N D
CL0 p.Arg    3 Trp details homologous mutations 2 2 2 D D ?
CL0,L0 p.Pro    5 Leu details homologous mutations 3 3 3 D D D
CL0,L0 p.Val   11 Ile details homologous mutations 2 7 7 N N ?
CL0,L0 p.Val   11 Cys details homologous mutations 1 1 1 N N ?
CL0,L0 p.Ser   13 Phe details homologous mutations 6 129 139 D D
CL0,L0 p.Ser   13 Ala details homologous mutations 2 16 17 D N ?
CL0,L0 p.Ser   13 Tyr details homologous mutations 1 1 2 D D ?
CL0,L0 p.Ser   13 Cys details homologous mutations 1 3 3 D D ?
CL0,L0 p.Lys   14 * details homologous mutations 2 2 2 - -
CL0,L0 p.Lys   14 Arg details homologous mutations 1 22 22 N N ?
CL0,L0 p.Leu   15 Pro details homologous mutations 3 12 12 D D ?
CL0,L0 p.Trp   19 Cys details homologous mutations 7 28 31 D D
CL0,L0 p.Trp   19 * details homologous mutations 1 1 1 - - ?
CL0,L0 p.Leu   24 Phe details homologous mutations 1 3 3 N N
CL0,L0 p.Gly   27 Glu details homologous mutations 6 13 18 D D
CL0,L0 p.Gly   27 * details homologous mutations 6 14 15 - -
CL0,L0 p.Gly   27 Arg details homologous mutations 2 11 11 D D
CL0,L0 p.Gly   27 Val details homologous mutations 1 4 5 D D ?
CL0,L0 p.Arg   29 Lys details homologous mutations 10 32 35 N N ?
CL0,L0 p.Gln   30 * details homologous mutations 10 11 11 - -
CL0,L0 p.Arg   31 Cys details homologous mutations 36 103 119 D N
CL0,L0 p.Arg   31 Leu details homologous mutations 10 50 54 D N
CL0,L0 p.Arg   31 His details homologous mutations 1 3 3 N N ?
CL0,L0 p.Leu   32 Met details homologous mutations 2 5 6 N N ?
CL0,L0 p.Asp   36 Asn details homologous mutations 1 3 4 D D ?
CL0,L0 p.Asp   36 Lys details homologous mutations 2 2 2 D D ?
CL0,L0 p.Tyr   38 Ala details homologous mutations 1 1 1 D D ?
CL0,L0 p.Gln   39 * details homologous mutations 16 21 22 - - D
CL0,L0 p.Ser   42 Phe details homologous mutations 9 19 21 D D D
CL0,L0 p.Asp   44 Val details homologous mutations 2 2 2 D D ?
CL0,L0 p.Asp   44 Gly details homologous mutations 2 3 3 D D
CL0,L0 p.Ala   46 Asp details homologous mutations 5 20 23 D N
CL0,L0 p.Asp   47 Ala details homologous mutations 1 5 5 N D ?
CL0,L0 p.Leu   49 Pro details homologous mutations 1 6 7 D D ?
CL0,L0 p.Ser   50 Pro details homologous mutations 5 27 30 D N
CL0,L0 p.Ser   50 Tyr details homologous mutations 3 8 9 N N
CL0,L0 p.Glu   54 Cys details homologous mutations 1 51 55 N D ?
CL0,L0 p.Glu   54 Ala details homologous mutations 2 15 15 N D ?
CL0,L0 p.Glu   56 Lys details homologous mutations 5 15 18 N N
CL0,L0 p.Glu   56 Leu details homologous mutations 1 1 1 N D ?
CL0,L0 p.Glu   56 Gly details homologous mutations 1 6 9 N N ?
CL0,L0 p.Trp   57 Gly details homologous mutations 5 14 16 D D
CL0,L0 p.Trp   57 * details homologous mutations 9 12 13 - - D
CL0,L0 p.Trp   57 Arg details homologous mutations 1 3 5 D D
CL0,L0 p.Asp   58 Cys details homologous mutations 1 51 52 N D ?
CL0,L0 p.Asp   58 Ala details homologous mutations 2 15 15 N N ?
CL0,L0 p.Asp   58 Asn details homologous mutations 3 37 42 N N
CL0,L0 p.Asp   58 Gly details homologous mutations 1 1 1 D D
CL0,L0 p.Glu   60 * details homologous mutations 103 199 221 - - D
CL0,L0 p.Glu   60 Ala details homologous mutations 1 1 1 D D D
CL0,L0 p.Glu   60 Lys details homologous mutations 4 18 21 D N D
CL0 p.Pro   67 Leu details homologous mutations 50 105 113 N D D
CL0 p.Pro   67 Ser details homologous mutations 2 66 71 D D ?
CL0 p.Lys   68 Glu details homologous mutations 5 17 18 D N
CL0 p.Lys   68 Asn details homologous mutations 5 8 8 D N
CL0 p.Lys   68 * details homologous mutations 1 1 1 - - ?
CL0 p.Lys   68 Arg details homologous mutations 1 23 23 N N ?
CL0 p.Leu   69 His details homologous mutations 4 55 60 D D ?
CL0 p.Leu   69 Gly details homologous mutations 1 2 2 D D ?
CL0 p.Leu   69 Ala details homologous mutations 1 1 1 D D ?
CL0 p.Ala   72 Asp details homologous mutations 3 3 3 D D
CL0 p.Leu   73 Phe details homologous mutations 1 4 4 D D ?
CL0 p.Arg   74 Trp details homologous mutations 76 242 300 D N D
CL0 p.Arg   74 Gln details homologous mutations 7 14 17 D N
CL0 p.Arg   75 Gln details homologous mutations 126 479 609 D N
CL0 p.Arg   75 * details homologous mutations 46 85 90 - - D
CL0 p.Arg   75 Glu details homologous mutations 1 1 1 D D D
CL0 p.Arg   75 Leu details homologous mutations 4 5 6 D D
CL0 p.Cys   76 Ser details homologous mutations 4 5 5 D D ?
CL0 p.Cys   76 Trp details homologous mutations 1 2 2 D D ?
CL0 p.Cys   76 Arg details homologous mutations 1 2 2 D D ?
CL0 p.Trp   79 * details homologous mutations 3 3 4 - -
CL0 p.Trp   79 Arg details homologous mutations 1 2 2 N D
CL0 p.Arg   80 Glu details homologous mutations 1 3 3 D N ?
CL0 p.Met   82 Ile details homologous mutations 1 6 6 N N ?
CL0 p.Met   82 Val details homologous mutations 3 9 12 N N ?
TMD1,TH1 p.Tyr   84 His details homologous mutations 2 3 3 D N ?
TMD1,TH1 p.Gly   85 Glu details homologous mutations 303 802 982 D D D
TMD1,TH1 p.Gly   85 Val details homologous mutations 8 27 30 D D
TMD1,TH1 p.Gly   85 Ala details homologous mutations 1 15 15 D N ?
TMD1,TH1 p.Phe   87 Ile details homologous mutations 3 21 21 D N
TMD1,TH1 p.Phe   87 Leu details homologous mutations 1 2 2 D N
TMD1,TH1 p.Phe   87 Cys details homologous mutations 1 2 2 D D ?
TMD1,TH1 p.Leu   88 * details homologous mutations 9 21 23 - -
TMD1,TH1 p.Leu   88 Ser details homologous mutations 5 5 5 N N
TMD1,TH1 p.Tyr   89 Cys details homologous mutations 3 27 30 N D
TMD1,TH1 p.Leu   90 Ser details homologous mutations 3 3 3 D N
TMD1,TH1 p.Gly   91 Arg details homologous mutations 47 137 147 D D D
TMD1,TH1 p.Gly   91 Glu details homologous mutations 3 11 15 D N D
TMD1,TH1 p.Gly   91 Cys details homologous mutations 3 8 8 D D D
TMD1,TH1 p.Gly   91 Ala details homologous mutations 3 22 26 D N D
TMD1,TH1 p.Glu   92 Lys details homologous mutations 40 113 134 N D D
TMD1,TH1 p.Glu   92 * details homologous mutations 16 20 23 - - D
TMD1,TH1 p.Glu   92 Ala details homologous mutations 3 25 44 D D D
TMD1,TH1 p.Glu   92 Asn details homologous mutations 1 1 1 D N D
TMD1,TH1 p.Glu   92 Cys details homologous mutations 2 6 6 D D D
TMD1,TH1 p.Thr   94 Ser details homologous mutations 1 1 1 N N ?
TMD1,TH1 p.Thr   94 Ile details homologous mutations 1 13 17 D N ?
TMD1,TH1 p.Lys   95 Asp details homologous mutations 17 23 23 D N ?
TMD1,TH1 p.Lys   95 Gln details homologous mutations 12 124 145 D N ?
TMD1,TH1 p.Lys   95 Arg details homologous mutations 2 3 3 N N ?
TMD1,TH1 p.Lys   95 Glu details homologous mutations 3 7 7 D N ?
TMD1,TH1 p.Lys   95 Met details homologous mutations 1 1 1 D N ?
TMD1,TH1 p.Lys   95 Cys details homologous mutations 12 109 120 D D ?
TMD1,TH1 p.Lys   95 Ala details homologous mutations 4 24 37 D N ?
TMD1,TH1 p.Lys   95 Ser details homologous mutations 3 34 58 D N ?
TMD1,TH1 p.Lys   95 His details homologous mutations 1 7 7 D N ?
TMD1,TH1 p.Ala   96 Glu details homologous mutations 2 2 2 D N
TMD1,TH1 p.Ala   96 Val details homologous mutations 1 3 3 N N ?
TMD1,TH1 p.Ala   96 Cys details homologous mutations 1 1 1 N N ?
TMD1,TH1 p.Val   97 Ala details homologous mutations 2 2 2 D D ?
TMD1,TH1 p.Gln   98 * details homologous mutations 8 17 23 - - D
TMD1,TH1 p.Gln   98 His details homologous mutations 1 1 1 D D D
TMD1,TH1 p.Gln   98 Arg details homologous mutations 27 65 76 N N
TMD1,TH1 p.Gln   98 Ala details homologous mutations 1 4 4 D D D
TMD1,TH1 p.Gln   98 Cys details homologous mutations 7 94 104 D D D
TMD1,TH1 p.Gln   98 Pro details homologous mutations 1 2 3 D D
TMD1,TH1 p.Gln   98 Lys details homologous mutations 1 10 10 D N D
TMD1,TH1 p.Pro   99 Leu details homologous mutations 12 52 60 D D
TMD1,TH1 p.Pro   99 Ala details homologous mutations 3 25 28 D D ?
TMD1,TH1 p.Pro   99 Cys details homologous mutations 6 17 17 D D ?
TMD1,TH1 p.Pro   99 Gly details homologous mutations 2 21 24 D D ?
TMD1,TH1 p.Leu  101 Cys details homologous mutations 1 2 3 N D ?
TMD1,TH1 p.Leu  101 * details homologous mutations 1 1 1 - -
TMD1,TH1 p.Leu  102 Pro details homologous mutations 1 27 37 D D
TMD1,TH1 p.Leu  102 Cys details homologous mutations 4 96 108 N D ?
TMD1,TH1 p.Leu  102 Arg details homologous mutations 1 2 2 D D ?
TMD1,TH1 p.Gly  103 * details homologous mutations 1 1 1 - - ?
TMD1,TH1 p.Gly  103 Cys details homologous mutations 1 4 4 D D ?
TMD1,TH1 p.Gly  103 Glu details homologous mutations 1 2 2 D D ?
TMD1,TH1 p.Arg  104 Cys details homologous mutations 6 47 49 D D ?
TMD1,TH1 p.Arg  104 Glu details homologous mutations 2 21 28 D N ?
TMD1,TH1 p.Arg  104 Gln details homologous mutations 3 18 21 N N ?
TMD1,EL1 p.Ile  105 Asn details homologous mutations 4 7 8 D D
TMD1,EL1 p.Ile  106 Cys details homologous mutations 1 4 4 N D ?
TMD1,EL1 p.Ala  107 Val details homologous mutations 1 6 6 N N ?
TMD1,EL1 p.Ala  107 Cys details homologous mutations 1 9 10 N N ?
TMD1,EL1 p.Ser  108 Phe details homologous mutations 5 19 19 N N
TMD1,EL1 p.Ser  108 Cys details homologous mutations 1 1 1 N D ?
TMD1,EL1 p.Tyr  109 Cys details homologous mutations 7 16 18 D D D
TMD1,EL1 p.Tyr  109 Asn details homologous mutations 2 2 3 D D
TMD1,EL1 p.Tyr  109 * details homologous mutations 1 3 3 - -
TMD1,EL1 p.Asp  110 Tyr details homologous mutations 3 4 4 D N
TMD1,EL1 p.Asp  110 His details homologous mutations 46 92 106 D N D
TMD1,EL1 p.Asp  110 Glu details homologous mutations 10 25 27 D N
TMD1,EL1 p.Asp  110 Asn details homologous mutations 1 1 1 D N D
TMD1,EL1 p.Asp  110 Cys details homologous mutations 2 51 55 D D D
TMD1,EL1 p.Asp  110 Arg details homologous mutations 1 36 44 D N D
TMD1,EL1 p.Pro  111 Leu details homologous mutations 5 15 16 N D
TMD1,EL1 p.Pro  111 Ala details homologous mutations 3 6 6 D N
TMD1,EL1 p.Asp  112 Gly details homologous mutations 1 2 2 N N ?
TMD1,EL1 p.Asp  112 Arg details homologous mutations 1 4 4 N N ?
TMD1,EL1 p.Lys  114 Glu details homologous mutations 1 2 2 N N ?
TMD1,EL1 p.Lys  114 Cys details homologous mutations 3 3 3 D N ?
TMD1,EL1 p.Lys  114 Asp details homologous mutations 1 9 9 N N ?
TMD1,EL1 p.Glu  115 Lys details homologous mutations 1 20 32 N N ?
TMD1,EL1 p.Glu  115 Ser details homologous mutations 1 2 2 N N ?
TMD1,EL1 p.Glu  115 Arg details homologous mutations 1 4 4 N N ?
TMD1,EL1 p.Glu  116 Lys details homologous mutations 7 39 71 N N
TMD1,EL1 p.Glu  116 * details homologous mutations 1 1 1 - - ?
TMD1,EL1 p.Glu  116 Arg details homologous mutations 1 41 49 N N ?
TMD1,EL1 p.Glu  116 Cys details homologous mutations 1 30 31 D D ?
TMD1,EL1 p.Glu  116 Asp details homologous mutations 1 8 8 N N ?
TMD1,EL1 p.Arg  117 His details homologous mutations 740 2973 3844 N N D
TMD1,EL1 p.Arg  117 Leu details homologous mutations 18 50 54 D N
TMD1,EL1 p.Arg  117 Cys details homologous mutations 82 180 213 D D D
TMD1,EL1 p.Arg  117 Pro details homologous mutations 10 18 19 D N
TMD1,EL1 p.Arg  117 Glu details homologous mutations 2 26 33 D N D
TMD1,EL1 p.Arg  117 Gln details homologous mutations 3 16 17 D N D
TMD1,EL1 p.Arg  117 Gly details homologous mutations 3 4 5 D N
TMD1,EL1 p.Arg  117 Met details homologous mutations 1 1 1 D N D
TMD1,EL1 p.Arg  117 Thr details homologous mutations 1 2 2 D N D
TMD1,EL1 p.Arg  117 Ala details homologous mutations 1 30 30 D N D
TMD1,EL1 p.Arg  117 Lys details homologous mutations 1 8 8 D N D
TMD1,EL1 p.Ser  118 Pro details homologous mutations 2 16 16 D N ?
TMD1,TH2 p.Ala  120 Thr details homologous mutations 22 47 51 N N
TMD1,TH2 p.Tyr  122 * details homologous mutations 75 247 305 - - D
TMD1,TH2 p.Tyr  122 Lys details homologous mutations 1 2 2 D D ?
TMD1,TH2 p.Tyr  122 His details homologous mutations 2 11 12 D N
TMD1,TH2 p.Tyr  122 Cys details homologous mutations 1 1 2 N D ?
TMD1,TH2 p.Ile  125 Thr details homologous mutations 8 30 33 N N
TMD1,TH2 p.Gly  126 Asp details homologous mutations 6 24 48 D D ?
TMD1,TH2 p.Gly  126 Ser details homologous mutations 3 21 21 N N
TMD1,TH2 p.Gly  126 Cys details homologous mutations 1 5 5 D D ?
TMD1,TH2 p.Cys  128 Ser details homologous mutations 2 3 3 N N ?
TMD1,TH2 p.Cys  128 Ala details homologous mutations 1 1 1 N N ?
TMD1,TH2 p.Ile  132 Met details homologous mutations 1 1 1 N N ?
TMD1,TH2 p.Arg  134 Gln details homologous mutations 1 9 11 D N ?
TMD1,TH2 p.Arg  134 Glu details homologous mutations 2 2 2 D N ?
TMD1,TH2 p.Leu  136 Pro details homologous mutations 1 3 3 D D ?
TMD1,TH2 p.Leu  137 His details homologous mutations 2 2 2 D D
TMD1,TH2 p.Leu  137 Pro details homologous mutations 1 2 2 D D ?
TMD1,TH2 p.Leu  137 Arg details homologous mutations 2 2 2 D D
TMD1,TH2 p.Leu  138 Pro details homologous mutations 1 1 1 D D ?
TMD1,TH2 p.His  139 Leu details homologous mutations 5 18 20 D D
TMD1,TH2 p.His  139 Arg details homologous mutations 10 23 25 N D
TMD1,TH2 p.His  139 Gln details homologous mutations 3 19 20 D D ?
TMD1,TH2 p.Pro  140 Ser details homologous mutations 1 4 4 N N
TMD1,CL1 p.Ala  141 Asp details homologous mutations 4 8 8 N N
TMD1,CL1 p.Ala  141 Gly details homologous mutations 1 4 4 D N ?
TMD1,CL1 p.Ile  148 Thr details homologous mutations 159 721 967 D N N
TMD1,CL1 p.Ile  148 Asn details homologous mutations 2 5 5 D D
TMD1,CL1 p.Gly  149 Arg details homologous mutations 17 76 91 D D
TMD1,CL1 p.Gly  149 * details homologous mutations 1 9 10 - - ?
TMD1,CL1 p.Gly  149 Trp details homologous mutations 1 7 8 D D ?
TMD1,CL1 p.Met  150 Lys details homologous mutations 1 4 5 D D ?
TMD1,CL1 p.Met  150 Val details homologous mutations 2 8 15 N D ?
TMD1,CL1 p.Gln  151 * details homologous mutations 3 5 5 - - ?
TMD1,CL1 p.Gln  151 Lys details homologous mutations 1 1 1 N N
TMD1,CL1 p.Met  152 Val details homologous mutations 4 9 15 N N
TMD1,CL1 p.Met  152 Arg details homologous mutations 4 4 4 D D
TMD1,CL1 p.Arg  153 Ile details homologous mutations 1 5 6 D D ?
TMD1,CL1 p.Arg  153 Cys details homologous mutations 1 1 1 D D ?
TMD1,CL1 p.Met  156 Val details homologous mutations 1 4 9 N N ?
TMD1,CL1 p.Met  156 Asn details homologous mutations 1 1 1 D D ?
TMD1,CL1 p.Phe  157 Cys details homologous mutations 3 19 19 N N ?
TMD1,CL1 p.Ser  158 Asn details homologous mutations 3 18 19 N N ?
TMD1,CL1 p.Ser  158 Thr details homologous mutations 2 6 6 N N
TMD1,CL1 p.Leu  159 Ser details homologous mutations 2 2 3 D N
TMD1,CL1 p.Tyr  161 Asp details homologous mutations 2 5 6 D D
TMD1,CL1 p.Tyr  161 Cys details homologous mutations 2 4 4 D D
TMD1,CL1 p.Tyr  161 Asn details homologous mutations 1 1 1 D D
TMD1,CL1 p.Thr  164 Ile details homologous mutations 3 13 14 N N ?
TMD1,CL1 p.Thr  164 Ser details homologous mutations 2 4 4 N N ?
TMD1,CL1 p.Leu  165 Ser details homologous mutations 5 7 9 D D
TMD1,CL1 p.Leu  165 * details homologous mutations 1 2 2 - - ?
TMD1,CL1 p.Lys  166 Glu details homologous mutations 4 11 12 D N
TMD1,CL1 p.Leu  167 Arg details homologous mutations 1 27 37 D D
TMD1,CL1 p.Arg  170 His details homologous mutations 18 30 31 N N
TMD1,CL1 p.Arg  170 Cys details homologous mutations 8 19 19 D D ?
TMD1,CL1 p.Arg  170 Leu details homologous mutations 2 5 5 D D ?
TMD1,CL1 p.Val  171 Cys details homologous mutations 1 8 10 N N ?
TMD1,CL1 p.Leu  172 Cys details homologous mutations 1 5 5 N N ?
TMD1,CL1 p.Ile  175 Val details homologous mutations 7 17 17 N N
TMD1,CL1 p.Ile  177 Phe details homologous mutations 1 1 1 D N ?
TMD1,CL1 p.Gly  178 Arg details homologous mutations 50 114 132 D D D
TMD1,CL1 p.Gly  178 Glu details homologous mutations 2 2 2 D D
TMD1,CL1 p.Gln  179 Lys details homologous mutations 7 16 18 D N
TMD1,CL1 p.Ser  182 Gly details homologous mutations 1 1 1 D N ?
TMD1,CL1 p.Leu  183 Ile details homologous mutations 3 14 15 D N
TMD1,CL1 p.Asn  186 Lys details homologous mutations 1 1 1 D N
TMD1,CL1 p.Asn  187 Lys details homologous mutations 2 4 4 D D ?
TMD1,CL1 p.Leu  188 Pro details homologous mutations 1 1 2 D D ?
TMD1,CL1 p.Asn  189 Lys details homologous mutations 1 1 1 D N
TMD1,CL1 p.Lys  190 Cys details homologous mutations 5 42 42 D D ?
TMD1,CL1 p.Lys  190 Glu details homologous mutations 1 1 1 D N ?
TMD1,CL1 p.Phe  191 Leu details homologous mutations 1 2 2 N N ?
TMD1,CL1 p.Asp  192 Gly details homologous mutations 9 20 24 D N
TMD1,CL1 p.Asp  192 Asn details homologous mutations 4 5 6 D N
TMD1,CL1 p.Asp  192 Cys details homologous mutations 1 1 1 D D ?
TMD1,CL1 p.Glu  193 Lys details homologous mutations 21 77 84 N N
TMD1,CL1 p.Glu  193 Cys details homologous mutations 1 1 1 D D D
TMD1,CL1 p.Glu  193 * details homologous mutations 3 4 4 - - D
TMD1,CL1 p.Gly  194 Val details homologous mutations 2 2 2 D N
TMD1,CL1 p.Gly  194 Arg details homologous mutations 2 5 5 D N ?
TMD1,CL1 p.Gly  194 Thr details homologous mutations 1 1 1 D N ?
TMD1,CL1 p.Leu  197 Cys details homologous mutations 1 1 1 D N ?
TMD1,TH3 p.Ala  198 Pro details homologous mutations 1 1 1 D D
TMD1,TH3 p.Ala  198 Cys details homologous mutations 1 1 1 D N D
TMD1,TH3 p.His  199 Tyr details homologous mutations 27 38 40 D D D
TMD1,TH3 p.His  199 Arg details homologous mutations 7 12 14 D D
TMD1,TH3 p.His  199 Gln details homologous mutations 2 2 2 D D
TMD1,TH3 p.His  199 Cys details homologous mutations 1 2 2 D D D
TMD1,TH3 p.Phe  200 Ile details homologous mutations 1 1 1 D N
TMD1,TH3 p.Phe  200 Cys details homologous mutations 1 1 1 D D ?
TMD1,TH3 p.Val  201 Met details homologous mutations 11 30 30 D N
TMD1,TH3 p.Trp  202 * details homologous mutations 3 5 6 - -
TMD1,TH3 p.Trp  202 Cys details homologous mutations 1 1 1 D D ?
TMD1,TH3 p.Ile  203 Met details homologous mutations 1 1 1 N N
TMD1,TH3 p.Ile  203 Cys details homologous mutations 1 2 2 D N ?
TMD1,TH3 p.Ala  204 Thr details homologous mutations 1 26 32 N N ?
TMD1,TH3 p.Ala  204 Leu details homologous mutations 2 6 6 D D ?
TMD1,TH3 p.Pro  205 Ser details homologous mutations 55 158 171 N D D
TMD1,TH3 p.Pro  205 Ala details homologous mutations 3 13 13 D D D
TMD1,TH3 p.Pro  205 Leu details homologous mutations 1 9 9 D D D
TMD1,TH3 p.Pro  205 Gly details homologous mutations 2 7 7 D D D
TMD1,TH3 p.Pro  205 Cys details homologous mutations 1 2 2 D D D
TMD1,TH3 p.Leu  206 Trp details homologous mutations 101 336 416 D D D
TMD1,TH3 p.Leu  206 Phe details homologous mutations 3 4 4 D N
TMD1,TH3 p.Leu  206 Val details homologous mutations 1 1 1 D N ?
TMD1,TH3 p.Leu  206 Tyr details homologous mutations 1 2 2 D N ?
TMD1,TH3 p.Leu  206 Arg details homologous mutations 1 1 1 D D ?
TMD1,TH3 p.Leu  206 Glu details homologous mutations 1 1 1 D D ?
TMD1,TH3 p.Gln  207 Leu details homologous mutations 4 19 21 D D ?
TMD1,TH3 p.Gln  207 Cys details homologous mutations 2 10 11 D D ?
TMD1,TH3 p.Gln  207 * details homologous mutations 2 8 9 - -
TMD1,TH3 p.Gln  207 Asn details homologous mutations 2 38 42 D D ?
TMD1,TH3 p.Gln  207 Ala details homologous mutations 1 10 10 D D ?
TMD1,TH3 p.Gln  207 Asp details homologous mutations 1 1 1 D D ?
TMD1,TH3 p.Gln  207 Trp details homologous mutations 1 2 2 D D ?
TMD1,TH3 p.Gln  207 Phe details homologous mutations 1 2 2 D D ?
TMD1,TH3 p.Gln  207 Ser details homologous mutations 1 3 3 D D ?
TMD1,TH3 p.Gln  207 Glu details homologous mutations 1 4 4 D N ?
TMD1,TH3 p.Ala  209 Ser details homologous mutations 3 4 4 D N
TMD1,TH3 p.Leu  210 Ala details homologous mutations 1 1 1 N D ?
TMD1,TH3 p.Leu  211 Cys details homologous mutations 1 3 3 N N ?
TMD1,TH3 p.Met  212 Ala details homologous mutations 1 2 2 N D ?
TMD1,TH3 p.Gly  213 Ala details homologous mutations 1 1 1 D N ?
TMD1,TH3 p.Gly  213 Glu details homologous mutations 1 2 2 D N ?
TMD1,TH3 p.Leu  214 Cys details homologous mutations 1 1 1 D D ?
TMD1,TH3 p.Trp  216 * details homologous mutations 6 11 12 - -
TMD1,TH3 p.Trp  216 Cys details homologous mutations 1 4 4 D D
TMD1,TH3 p.Glu  217 Arg details homologous mutations 1 6 7 D N ?
TMD1,TH3 p.Glu  217 Gly details homologous mutations 31 130 146 N N D
TMD1,TH3 p.Glu  217 Ser details homologous mutations 2 17 19 N N ?
TMD1,TH3 p.Glu  217 Val details homologous mutations 2 11 11 D D ?
TMD1,TH3 p.Glu  217 Phe details homologous mutations 2 9 9 D D ?
TMD1,TH3 p.Glu  217 Cys details homologous mutations 2 14 16 D D ?
TMD1,TH3 p.Leu  218 * details homologous mutations 5 10 11 - -
TMD1,EL2 p.Gln  220 Lys details homologous mutations 2 11 12 D N D
TMD1,EL2 p.Gln  220 * details homologous mutations 26 50 53 - - D
TMD1,EL2 p.Gln  220 Ala details homologous mutations 1 1 1 N N D
TMD1,EL2 p.Gln  220 Arg details homologous mutations 2 13 13 D N
TMD1,EL2 p.Gln  220 Asn details homologous mutations 1 6 6 N N D
TMD1,EL2 p.Gln  220 Gly details homologous mutations 1 5 5 N N D
TMD1,EL2 p.Gln  220 Glu details homologous mutations 1 6 7 N N D
TMD1,EL2 p.Gln  220 Trp details homologous mutations 2 11 11 D N D
TMD1,TH4 p.Ala  221 Asp details homologous mutations 1 2 2 D N ?
TMD1,TH4 p.Ser  222 Ala details homologous mutations 2 3 3 N N ?
TMD1,TH4 p.Ser  222 Glu details homologous mutations 2 14 15 D D ?
TMD1,TH4 p.Ser  222 Gly details homologous mutations 1 5 8 D D ?
TMD1,TH4 p.Ser  222 Asp details homologous mutations 1 1 1 D D ?
TMD1,TH4 p.Ala  223 Asp details homologous mutations 1 1 1 D D ?
TMD1,TH4 p.Phe  224 Ala details homologous mutations 1 1 1 D D ?
TMD1,TH4 p.Phe  224 Asp details homologous mutations 1 2 2 D D ?
TMD1,TH4 p.Cys  225 Arg details homologous mutations 7 32 37 D D
TMD1,TH4 p.Cys  225 Ala details homologous mutations 4 5 5 D N ?
TMD1,TH4 p.Cys  225 Ser details homologous mutations 5 7 7 D D ?
TMD1,TH4 p.Cys  225 * details homologous mutations 3 3 4 - -
TMD1,TH4 p.Gly  226 Ala details homologous mutations 1 1 1 N D ?
TMD1,TH4 p.Gly  226 Asp details homologous mutations 1 2 2 D D ?
TMD1,TH4 p.Leu  227 Arg details homologous mutations 9 11 12 D D
TMD1,TH4 p.Gly  228 Leu details homologous mutations 1 2 2 D N ?
TMD1,TH4 p.Gly  228 Asp details homologous mutations 1 3 3 D N ?
TMD1,TH4 p.Phe  229 Ala details homologous mutations 1 1 1 N N ?
TMD1,TH4 p.Phe  229 Arg details homologous mutations 1 2 2 D N ?
TMD1,TH4 p.Leu  230 Asp details homologous mutations 1 2 2 D D ?
TMD1,TH4 p.Ile  231 Asp details homologous mutations 4 51 61 D D ?
TMD1,TH4 p.Val  232 Asp details homologous mutations 43 343 413 D D
TMD1,TH4 p.Val  232 Lys details homologous mutations 2 15 15 D D ?
TMD1,TH4 p.Val  232 Ala details homologous mutations 1 2 2 N N ?
TMD1,TH4 p.Val  232 Glu details homologous mutations 2 48 53 D D ?
TMD1,TH4 p.Val  232 Asn details homologous mutations 1 9 11 D D ?
TMD1,TH4 p.Val  232 Gln details homologous mutations 1 6 7 D D ?
TMD1,TH4 p.Val  232 Arg details homologous mutations 1 11 11 D D ?
TMD1,TH4 p.Val  232 * details homologous mutations 1 1 1 - - ?
TMD1,TH4 p.Leu  233 Asp details homologous mutations 1 1 1 D D ?
TMD1,TH4 p.Ala  234 Asp details homologous mutations 1 1 1 D N ?
TMD1,TH4 p.Phe  236 Asp details homologous mutations 1 1 1 D D ?
TMD1,TH4 p.Phe  236 Arg details homologous mutations 1 2 2 D D ?
TMD1,TH4 p.Gln  237 Ala details homologous mutations 1 1 1 D D ?
TMD1,TH4 p.Gln  237 Glu details homologous mutations 2 2 2 D N
TMD1,TH4 p.Gln  237 Leu details homologous mutations 2 9 15 D D ?
TMD1,TH4 p.Gln  237 Asp details homologous mutations 1 1 1 D N ?
TMD1,TH4 p.Ala  238 Val details homologous mutations 1 3 3 D D
TMD1,TH4 p.Ala  238 Asp details homologous mutations 1 3 3 D D ?
TMD1,TH4 p.Gly  239 Asp details homologous mutations 1 3 3 D N ?
TMD1,TH4 p.Gly  239 Arg details homologous mutations 1 2 2 N N
TMD1,CL2 p.Gly  241 Arg details homologous mutations 3 3 3 D N
TMD1,CL2 p.Gly  241 Asp details homologous mutations 2 6 6 D N ?
TMD1,CL2 p.Arg  242 Glu details homologous mutations 2 8 9 D N ?
TMD1,CL2 p.Met  244 Lys details homologous mutations 2 7 7 D D
TMD1,CL2 p.Lys  246 Asn details homologous mutations 1 5 6 N N ?
TMD1,CL2 p.Arg  248 Glu details homologous mutations 1 5 6 D N ?
TMD1,CL2 p.Arg  248 Thr details homologous mutations 2 5 5 D D
TMD1,CL2 p.Arg  248 Cys details homologous mutations 1 12 12 D D ?
TMD1,CL2 p.Asp  249 Tyr details homologous mutations 1 3 3 D N ?
TMD1,CL2 p.Gln  250 Arg details homologous mutations 1 2 2 N N ?
TMD1,CL2 p.Arg  251 Glu details homologous mutations 1 2 2 D N ?
TMD1,CL2 p.Arg  251 Cys details homologous mutations 1 6 6 D D ?
TMD1,CL2 p.Lys  254 Cys details homologous mutations 1 1 1 N N ?
TMD1,CL2 p.Glu  257 * details homologous mutations 1 4 5 - - ?
TMD1,CL2 p.Arg  258 Gly details homologous mutations 19 42 45 D D
TMD1,CL2 p.Ser  263 His details homologous mutations 1 9 18 D D ?
TMD1,CL2 p.Glu  264 Val details homologous mutations 6 12 16 D D ?
TMD1,CL2 p.Met  265 Val details homologous mutations 4 37 42 N N ?
TMD1,CL2 p.Met  265 Arg details homologous mutations 2 5 5 D D
TMD1,CL2 p.Glu  267 Lys details homologous mutations 2 8 8 D N ?
TMD1,CL2 p.Glu  267 Ala details homologous mutations 2 7 9 N N ?
TMD1,CL2 p.Glu  267 Arg details homologous mutations 2 47 54 D N ?
TMD1,CL2 p.Glu  267 Cys details homologous mutations 1 9 9 D D ?
TMD1,CL2 p.Glu  267 Gly details homologous mutations 1 1 1 D N ?
TMD1,CL2 p.Asn  268 Cys details homologous mutations 1 6 6 D D ?
TMD1,CL2 p.Ala  274 Cys details homologous mutations 1 1 1 N N ?
TMD1,CL2 p.Tyr  275 * details homologous mutations 2 8 8 - - D
TMD1,CL2 p.Tyr  275 Ser details homologous mutations 1 1 1 D D ?
TMD1,CL2 p.Tyr  275 Phe details homologous mutations 1 1 1 D D ?
TMD1,CL2 p.Tyr  275 Glu details homologous mutations 1 1 1 D D ?
TMD1,CL2 p.Tyr  275 Leu details homologous mutations 1 2 2 D D ?
TMD1,CL2 p.Tyr  275 Lys details homologous mutations 1 1 1 D D ?
TMD1,CL2 p.Cys  276 * details homologous mutations 5 6 6 - - D
TMD1,CL2 p.Cys  276 Ser details homologous mutations 5 7 7 N N ?
TMD1,CL2 p.Trp  277 Arg details homologous mutations 1 11 12 D D
TMD1,CL2 p.Glu  279 * details homologous mutations 1 1 1 - - ?
TMD1,CL2 p.Glu  279 Asp details homologous mutations 1 1 1 N N ?
TMD1,CL2 p.Met  281 Thr details homologous mutations 2 3 3 D D
TMD1,CL2 p.Met  281 Arg details homologous mutations 1 5 5 D D ?
TMD1,CL2 p.Met  284 Thr details homologous mutations 1 1 2 N N ?
TMD1,CL2 p.Ile  285 Phe details homologous mutations 2 4 4 N D D
TMD1,CL2 p.Asn  287 Tyr details homologous mutations 12 98 118 N N
TMD1,CL2 p.Asn  287 Lys details homologous mutations 2 10 10 N N
TMD1,CL2 p.Gln  290 * details homologous mutations 1 1 1 - -
TMD1,CL2 p.Glu  292 Lys details homologous mutations 3 5 6 D D
TMD1,CL2 p.Glu  292 * details homologous mutations 1 1 1 - - ?
TMD1,CL2 p.Lys  294 Cys details homologous mutations 1 1 1 N D ?
TMD1,CL2 p.Leu  295 Gln details homologous mutations 1 1 1 N N ?
TMD1,CL2 p.Arg  297 Gln details homologous mutations 27 78 95 D N N
TMD1,CL2 p.Arg  297 Trp details homologous mutations 2 6 7 D D
TMD1,CL2 p.Arg  297 Cys details homologous mutations 1 1 1 D D ?
TMD1,CL2 p.Lys  298 Cys details homologous mutations 1 1 1 D D ?
TMD1,CL2 p.Ala  299 Thr details homologous mutations 1 2 2 N N ?
TMD1,CL2 p.Tyr  301 Cys details homologous mutations 6 10 10 D D
TMD1,CL2 p.Val  302 Cys details homologous mutations 1 3 4 N N ?
TMD1,CL2 p.Arg  303 Glu details homologous mutations 2 17 18 D N ?
TMD1,CL2 p.Arg  303 Gln details homologous mutations 6 54 58 D N ?
TMD1,CL2 p.Arg  303 Lys details homologous mutations 3 3 3 D N ?
TMD1,CL2 p.Arg  303 Cys details homologous mutations 3 22 23 D D ?
TMD1,TH5 p.Tyr  304 * details homologous mutations 1 1 1 - -
TMD1,TH5 p.Phe  305 Val details homologous mutations 1 3 3 D N
TMD1,TH5 p.Ser  307 Asn details homologous mutations 2 7 7 N N
TMD1,TH5 p.Ala  309 Gly details homologous mutations 3 5 5 D N
TMD1,TH5 p.Ala  309 Asp details homologous mutations 1 5 5 D N ?
TMD1,TH5 p.Ala  309 Ser details homologous mutations 1 1 1 N N ?
TMD1,TH5 p.Phe  310 Arg details homologous mutations 1 2 2 D D ?
TMD1,TH5 p.Phe  311 Leu details homologous mutations 13 20 23 D N D
TMD1,TH5 p.Phe  312 Arg details homologous mutations 1 2 2 D D ?
TMD1,TH5 p.Gly  314 Glu details homologous mutations 22 64 70 D N
TMD1,TH5 p.Gly  314 Ala details homologous mutations 4 16 20 D N ?
TMD1,TH5 p.Gly  314 Arg details homologous mutations 5 23 26 D N
TMD1,TH5 p.Gly  314 Gln details homologous mutations 2 19 24 D N ?
TMD1,TH5 p.Gly  314 Asp details homologous mutations 2 18 22 D N ?
TMD1,TH5 p.Gly  314 Val details homologous mutations 1 2 2 D N
TMD1,TH5 p.Phe  315 Ser details homologous mutations 1 4 4 D N ?
TMD1,TH5 p.Phe  316 Leu details homologous mutations 2 2 2 N N ?
TMD1,TH5 p.Val  317 Ala details homologous mutations 2 7 7 N N ?
TMD1,TH5 p.Val  317 Glu details homologous mutations 2 78 89 D D ?
TMD1,TH5 p.Val  317 Gln details homologous mutations 1 15 16 D D ?
TMD1,TH5 p.Val  318 Ala details homologous mutations 1 2 2 N N ?
TMD1,TH5 p.Phe  319 Val details homologous mutations 1 3 3 N N ?
TMD1,TH5 p.Leu  320 Phe details homologous mutations 1 1 1 N N
TMD1,TH5 p.Leu  320 Val details homologous mutations 7 12 15 N N D
TMD1,TH5 p.Ser  321 Ala details homologous mutations 1 1 1 N N ?
TMD1,TH5 p.Val  322 Ala details homologous mutations 3 7 7 D N ?
TMD1,TH5 p.Val  322 Met details homologous mutations 1 1 1 N N
TMD1,TH5 p.Leu  323 Pro details homologous mutations 1 5 8 D N ?
TMD1,EL3 p.Pro  324 Ala details homologous mutations 1 4 4 N N ?
TMD1,EL3 p.Pro  324 Gly details homologous mutations 1 4 4 N D ?
TMD1,EL3 p.Tyr  325 Cys details homologous mutations 2 4 4 D D ?
TMD1,EL3 p.Ala  326 Cys details homologous mutations 1 1 1 N N ?
TMD1,EL3 p.Leu  327 Arg details homologous mutations 4 7 8 D D ?
TMD1,EL3 p.Leu  327 Cys details homologous mutations 1 1 1 N D ?
TMD1,EL3 p.Ile  328 Cys details homologous mutations 1 1 1 N N ?
TMD1,EL3 p.Lys  329 Ala details homologous mutations 4 10 10 N N ?
TMD1,EL3 p.Lys  329 Cys details homologous mutations 2 5 5 D N ?
TMD1,EL3 p.Lys  329 Glu details homologous mutations 1 2 2 D N ?
TMD1,EL3 p.Gly  330 * details homologous mutations 17 23 24 - - D
TMD1,EL3 p.Gly  330 Cys details homologous mutations 2 2 2 D D D
TMD1,EL3 p.Ile  331 Cys details homologous mutations 5 27 32 D D ?
TMD1,EL3 p.Ile  332 Cys details homologous mutations 2 2 2 N N ?
TMD1,EL3 p.Ile  332 Lys details homologous mutations 1 1 1 N N ?
TMD1,EL3 p.Leu  333 Ala details homologous mutations 1 1 1 N N D
TMD1,EL3 p.Leu  333 Cys details homologous mutations 7 48 56 N N D
TMD1,EL3 p.Arg  334 Trp details homologous mutations 377 869 1045 D D D
TMD1,EL3 p.Arg  334 Leu details homologous mutations 10 29 31 D N
TMD1,EL3 p.Arg  334 Gln details homologous mutations 21 99 118 D N
TMD1,EL3 p.Arg  334 Cys details homologous mutations 40 527 605 D D D
TMD1,EL3 p.Arg  334 Ala details homologous mutations 12 48 57 D N D
TMD1,EL3 p.Arg  334 His details homologous mutations 7 54 59 D N D
TMD1,EL3 p.Arg  334 Glu details homologous mutations 7 38 40 D N D
TMD1,EL3 p.Arg  334 Lys details homologous mutations 4 30 31 D N D
TMD1,EL3 p.Arg  334 Asp details homologous mutations 2 17 17 D N D
TMD1,EL3 p.Arg  334 * details homologous mutations 2 2 2 - - D
TMD1,EL3 p.Arg  334 Thr details homologous mutations 1 1 1 D N D
TMD1,EL3 p.Lys  335 Glu details homologous mutations 37 161 173 D N ?
TMD1,EL3 p.Lys  335 Ile details homologous mutations 1 3 3 D N ?
TMD1,EL3 p.Lys  335 Phe details homologous mutations 4 17 18 D D ?
TMD1,EL3 p.Lys  335 Ala details homologous mutations 16 88 102 D N ?
TMD1,EL3 p.Lys  335 Cys details homologous mutations 12 67 79 D D ?
TMD1,EL3 p.Lys  335 Gln details homologous mutations 1 1 1 N N ?
TMD1,EL3 p.Lys  335 Asp details homologous mutations 3 20 25 D N ?
TMD1,EL3 p.Lys  335 Arg details homologous mutations 1 13 17 N N ?
TMD1,EL3 p.Lys  335 His details homologous mutations 2 12 12 D N ?
TMD1,TH6 p.Ile  336 Lys details homologous mutations 32 86 98 D D D
TMD1,TH6 p.Ile  336 Ala details homologous mutations 3 10 14 D N ?
TMD1,TH6 p.Ile  336 Cys details homologous mutations 4 8 8 D N ?
TMD1,TH6 p.Ile  336 Leu details homologous mutations 1 3 3 D N ?
TMD1,TH6 p.Phe  337 Ser details homologous mutations 11 207 235 D D ?
TMD1,TH6 p.Phe  337 Ala details homologous mutations 14 161 188 D D ?
TMD1,TH6 p.Phe  337 Tyr details homologous mutations 3 23 23 D N ?
TMD1,TH6 p.Phe  337 Cys details homologous mutations 13 84 88 D D ?
TMD1,TH6 p.Phe  337 Glu details homologous mutations 1 1 1 D D ?
TMD1,TH6 p.Phe  337 Leu details homologous mutations 2 16 16 D D ?
TMD1,TH6 p.Phe  337 Trp details homologous mutations 1 3 3 D D ?
TMD1,TH6 p.Phe  337 Arg details homologous mutations 2 8 9 D D ?
TMD1,TH6 p.Thr  338 Ile details homologous mutations 58 127 154 D D D
TMD1,TH6 p.Thr  338 Ala details homologous mutations 35 245 271 D N
TMD1,TH6 p.Thr  338 Ser details homologous mutations 5 28 29 D N ?
TMD1,TH6 p.Thr  338 Met details homologous mutations 1 1 1 D D ?
TMD1,TH6 p.Thr  338 Glu details homologous mutations 1 16 17 D D ?
TMD1,TH6 p.Thr  338 Gln details homologous mutations 1 1 1 D D ?
TMD1,TH6 p.Thr  338 Cys details homologous mutations 21 421 554 D D ?
TMD1,TH6 p.Thr  338 His details homologous mutations 3 18 35 D D ?
TMD1,TH6 p.Thr  338 Phe details homologous mutations 1 4 4 D D ?
TMD1,TH6 p.Thr  338 Asn details homologous mutations 1 15 15 D N ?
TMD1,TH6 p.Thr  338 Val details homologous mutations 1 13 13 D N ?
TMD1,TH6 p.Thr  338 Lys details homologous mutations 1 2 2 D D ?
TMD1,TH6 p.Thr  338 Arg details homologous mutations 1 1 1 D D ?
TMD1,TH6 p.Thr  339 Ala details homologous mutations 6 25 31 N N ?
TMD1,TH6 p.Thr  339 Val details homologous mutations 3 29 32 D N ?
TMD1,TH6 p.Thr  339 Cys details homologous mutations 6 9 9 D N ?
TMD1,TH6 p.Thr  339 Ser details homologous mutations 1 3 4 N N ?
TMD1,TH6 p.Thr  339 Phe details homologous mutations 1 2 3 D N ?
TMD1,TH6 p.Thr  339 Tyr details homologous mutations 1 2 3 D D ?
TMD1,TH6 p.Ile  340 Ala details homologous mutations 2 10 14 N N ?
TMD1,TH6 p.Ile  340 Cys details homologous mutations 3 3 4 N D ?
TMD1,TH6 p.Ile  340 Asn details homologous mutations 1 6 6 D D ?
TMD1,TH6 p.Ser  341 Ala details homologous mutations 24 169 184 D N D
TMD1,TH6 p.Ser  341 Thr details homologous mutations 2 13 13 D N D
TMD1,TH6 p.Ser  341 Glu details homologous mutations 2 25 26 D D D
TMD1,TH6 p.Ser  341 Cys details homologous mutations 12 44 45 D D D
TMD1,TH6 p.Ser  341 Lys details homologous mutations 2 17 21 D D D
TMD1,TH6 p.Ser  341 Arg details homologous mutations 1 1 1 D D D
TMD1,TH6 p.Ser  341 Pro details homologous mutations 4 7 9 D D D
TMD1,TH6 p.Phe  342 Trp details homologous mutations 1 2 5 D N ?
TMD1,TH6 p.Phe  342 Cys details homologous mutations 2 2 2 D D ?
TMD1,TH6 p.Phe  342 Ala details homologous mutations 2 38 52 D D ?
TMD1,TH6 p.Cys  343 Ser details homologous mutations 5 13 13 N N ?
TMD1,TH6 p.Cys  343 Val details homologous mutations 1 1 1 D N ?
TMD1,TH6 p.Cys  343 Leu details homologous mutations 1 2 2 D N ?
TMD1,TH6 p.Cys  343 Thr details homologous mutations 1 2 2 N N ?
TMD1,TH6 p.Cys  343 Ala details homologous mutations 2 5 9 N N ?
TMD1,TH6 p.Ile  344 Ala details homologous mutations 4 17 22 N N ?
TMD1,TH6 p.Ile  344 Cys details homologous mutations 17 107 130 N N ?
TMD1,TH6 p.Ile  344 Lys details homologous mutations 4 110 131 N N ?
TMD1,TH6 p.Ile  344 His details homologous mutations 1 7 8 D N ?
TMD1,TH6 p.Ile  344 Arg details homologous mutations 1 4 4 N N ?
TMD1,TH6 p.Val  345 Cys details homologous mutations 9 37 40 D D ?
TMD1,TH6 p.Val  345 Ala details homologous mutations 1 4 8 N N ?
TMD1,TH6 p.Val  345 Lys details homologous mutations 3 40 42 D D ?
TMD1,TH6 p.Val  345 His details homologous mutations 1 11 12 D D ?
TMD1,TH6 p.Val  345 Arg details homologous mutations 1 2 2 D D ?
TMD1,TH6 p.Leu  346 Pro details homologous mutations 12 120 154 D D
TMD1,TH6 p.Leu  346 Cys details homologous mutations 2 3 3 D D ?
TMD1,TH6 p.Leu  346 Ala details homologous mutations 1 3 7 D D ?
TMD1,TH6 p.Leu  346 Glu details homologous mutations 1 1 1 D D ?
TMD1,TH6 p.Leu  346 Arg details homologous mutations 2 4 4 D D ?
TMD1,TH6 p.Arg  347 Pro details homologous mutations 376 709 787 D N D
TMD1,TH6 p.Arg  347 Cys details homologous mutations 18 54 56 D D
TMD1,TH6 p.Arg  347 His details homologous mutations 185 394 468 D N D
TMD1,TH6 p.Arg  347 Glu details homologous mutations 24 134 144 D N ?
TMD1,TH6 p.Arg  347 Asp details homologous mutations 40 271 318 D D ?
TMD1,TH6 p.Arg  347 Lys details homologous mutations 3 17 19 D N ?
TMD1,TH6 p.Arg  347 Leu details homologous mutations 19 35 35 D N D
TMD1,TH6 p.Arg  347 Trp details homologous mutations 1 1 1 D D ?
TMD1,TH6 p.Arg  347 Ile details homologous mutations 2 14 15 D D ?
TMD1,TH6 p.Arg  347 Ala details homologous mutations 5 52 59 D N ?
TMD1,TH6 p.Arg  347 Gln details homologous mutations 1 1 1 D N ?
TMD1,TH6 p.Met  348 Lys details homologous mutations 12 81 111 D D
TMD1,TH6 p.Met  348 Cys details homologous mutations 16 80 90 D D ?
TMD1,TH6 p.Met  348 Val details homologous mutations 3 9 9 N N ?
TMD1,TH6 p.Met  348 Thr details homologous mutations 1 1 1 D D ?
TMD1,TH6 p.Met  348 Ala details homologous mutations 2 10 15 D D ?
TMD1,TH6 p.Met  348 Arg details homologous mutations 1 2 2 D D ?
TMD1,TH6 p.Met  348 Asn details homologous mutations 1 1 1 D D ?
TMD1,TH6 p.Met  348 Ile details homologous mutations 1 1 1 N N ?
TMD1,TH6 p.Met  348 Glu details homologous mutations 1 1 2 D D ?
TMD1,TH6 p.Ala  349 Val details homologous mutations 14 20 21 N N D
TMD1,TH6 p.Ala  349 Cys details homologous mutations 5 7 8 D N ?
TMD1,TH6 p.Ala  349 Ser details homologous mutations 2 5 9 N N ?
TMD1,TH6 p.Ala  349 Lys details homologous mutations 1 11 11 D N ?
TMD1,TH6 p.Val  350 Cys details homologous mutations 3 4 4 D N ?
TMD1,TH6 p.Val  350 Ala details homologous mutations 1 9 14 D N ?
TMD1,TH6 p.Val  350 Arg details homologous mutations 1 2 2 D D ?
TMD1,TH6 p.Thr  351 Ala details homologous mutations 2 6 10 D N ?
TMD1,TH6 p.Thr  351 Cys details homologous mutations 12 67 69 D N ?
TMD1,TH6 p.Thr  351 Ser details homologous mutations 7 10 10 D N
TMD1,TH6 p.Thr  351 Arg details homologous mutations 1 1 1 D N ?
TMD1,TH6 p.Arg  352 Gln details homologous mutations 65 172 189 D N D
TMD1,TH6 p.Arg  352 His details homologous mutations 3 18 18 D N D
TMD1,TH6 p.Arg  352 Cys details homologous mutations 25 234 285 D N D
TMD1,TH6 p.Arg  352 Glu details homologous mutations 7 73 156 D N D
TMD1,TH6 p.Arg  352 Trp details homologous mutations 8 14 15 D N D
TMD1,TH6 p.Arg  352 Lys details homologous mutations 3 28 36 D N D
TMD1,TH6 p.Arg  352 Ala details homologous mutations 6 79 100 D N D
TMD1,TH6 p.Arg  352 Gly details homologous mutations 1 2 2 D N D
TMD1,TH6 p.Gln  353 Cys details homologous mutations 8 35 36 D N ?
TMD1,TH6 p.Gln  353 His details homologous mutations 1 1 1 D N
TMD1,TH6 p.Gln  353 Ala details homologous mutations 1 4 8 D N ?
TMD1,TH6 p.Gln  353 * details homologous mutations 2 2 2 - -
CL3 p.Phe  354 Ile details homologous mutations 1 1 1 N N ?
CL3 p.Phe  354 Arg details homologous mutations 1 2 2 D D ?
CL3 p.Pro  355 Ser details homologous mutations 2 6 7 D D ?
CL3 p.Pro  355 Leu details homologous mutations 2 3 3 D D ?
CL3 p.Pro  355 Ala details homologous mutations 1 52 62 D D ?
CL3 p.Pro  355 Phe details homologous mutations 1 5 6 D D ?
CL3 p.Trp  356 Cys details homologous mutations 5 39 48 N N ?
CL3 p.Trp  356 * details homologous mutations 2 2 2 - -
CL3 p.Ala  357 Thr details homologous mutations 2 7 7 D N ?
CL3 p.Val  358 Ile details homologous mutations 1 3 3 N N ?
CL3 p.Gln  359 Lys details homologous mutations 21 42 47 N N ?
CL3 p.Gln  359 Arg details homologous mutations 2 3 3 D N
CL3 p.Thr  360 Lys details homologous mutations 18 37 41 D N ?
CL3 p.Trp  361 Arg details homologous mutations 7 12 16 D D
CL3 p.Tyr  362 * details homologous mutations 2 4 4 - -
CL3 p.Ser  364 Pro details homologous mutations 11 17 19 D N
CL3 p.Leu  365 Pro details homologous mutations 2 2 2 D N
CL3 p.Asn  369 * details homologous mutations 1 4 4 - - ?
CL3 p.Lys  370 * details homologous mutations 3 20 21 - - ?
CL3 p.Lys  370 Cys details homologous mutations 1 13 13 D D ?
CL3 p.Gln  372 * details homologous mutations 1 1 1 - - ?
CL3 p.Phe  374 Ala details homologous mutations 1 14 26 D D ?
CL3 p.Leu  375 Phe details homologous mutations 6 19 26 N D
CL3 p.Leu  375 Ala details homologous mutations 1 5 9 D D ?
CL3 p.Gln  378 Arg details homologous mutations 1 3 3 N N ?
CL3 p.Glu  379 Lys details homologous mutations 1 1 1 N D
CL3 p.Glu  379 * details homologous mutations 1 1 1 - -
CL3 p.Tyr  380 Cys details homologous mutations 1 3 3 N N ?
CL3 p.Leu  383 Ser details homologous mutations 1 5 5 N N
CL3 p.Thr  388 Met details homologous mutations 2 4 4 N N ?
CL3 p.Thr  388 Ile details homologous mutations 1 1 1 N N ?
CL3 p.Thr  388 Lys details homologous mutations 1 6 6 N N ?
CL3 p.Thr  388 Arg details homologous mutations 1 2 2 N N ?
CL3 p.Val  392 Gly details homologous mutations 4 5 7 D D
CL3 p.Val  392 Ala details homologous mutations 1 1 1 N N
CL3 p.Met  394 Arg details homologous mutations 1 1 2 N N
CL3 p.Val  397 Ala details homologous mutations 1 6 6 N N ?
CL3 p.Ala  399 Asp details homologous mutations 2 2 2 D N
CL3 p.Trp  401 * details homologous mutations 13 22 32 - - D
CL3 p.Trp  401 Gly details homologous mutations 13 111 123 D D ?
CL3 p.Trp  401 Phe details homologous mutations 7 92 109 N D ?
CL3 p.Trp  401 Tyr details homologous mutations 2 24 26 N D ?
CL3 p.Trp  401 Ile details homologous mutations 2 4 5 D D ?
CL3 p.Trp  401 Ala details homologous mutations 1 2 2 D D ?
CL3 p.Glu  402 * details homologous mutations 2 9 9 - - ?
CL3 p.Glu  402 Cys details homologous mutations 1 11 11 N N ?
CL3 p.Glu  403 Asp details homologous mutations 2 3 3 N N
CL3 p.Gly  406 Ala details homologous mutations 1 8 8 N N ?
CL3 p.Glu  407 Cys details homologous mutations 1 3 3 N D ?
CL3 p.Glu  407 Gln details homologous mutations 1 4 6 N N ?
CL3 p.Leu  408 Cys details homologous mutations 1 7 7 N N ?
CL3 p.Leu  408 Ala details homologous mutations 1 2 2 D N ?
CL3 p.Phe  409 Leu details homologous mutations 10 14 14 N N ?
CL3 p.Phe  409 Gly details homologous mutations 2 2 2 D N ?
CL3 p.Lys  411 Glu details homologous mutations 1 6 6 N N ?
CL3 p.Gln  414 * details homologous mutations 5 18 21 - -
CL3 p.Asn  416 Ser details homologous mutations 3 6 12 N N ?
CL3 p.Asn  417 Lys details homologous mutations 1 1 1 N N N
CL3 p.Asn  418 Ser details homologous mutations 2 2 2 N N
CL3 p.Arg  419 Ile details homologous mutations 1 8 8 N N ?
CL3 p.Lys  420 Ala details homologous mutations 1 8 8 N N ?
CL3 p.Thr  421 Ala details homologous mutations 2 10 11 N N ?
CL3 p.Ser  422 Ala details homologous mutations 5 18 22 N N ?
CL3 p.Ser  422 Asp details homologous mutations 3 7 7 N N ?
CL3 p.Ser  422 Pro details homologous mutations 4 7 12 N N ?
CL3,NBD1 p.Gly  424 Ser details homologous mutations 4 5 5 N N ?
CL3,NBD1 p.Asp  426 Cys details homologous mutations 1 1 1 N N ?
CL3,NBD1 p.Phe  429 Cys details homologous mutations 1 5 5 N N ?
CL3,NBD1 p.Phe  429 Ser details homologous mutations 22 53 67 N N ?
CL3,NBD1 p.Phe  429 Asn details homologous mutations 1 2 2 D N ?
CL3,NBD1 p.Phe  430 Cys details homologous mutations 1 5 5 N N ?
CL3,NBD1 p.Phe  430 Gly details homologous mutations 2 2 2 D D ?
CL3,NBD1 p.Ser  431 Gly details homologous mutations 3 3 3 N N ?
CL3,NBD1 p.Phe  433 Cys details homologous mutations 1 5 5 D N ?
CL3,NBD1 p.Phe  433 Leu details homologous mutations 11 15 15 N N ?
CL3,NBD1 p.Ser  434 Cys details homologous mutations 2 9 9 N N ?
CL3,NBD1 p.Ser  434 Pro details homologous mutations 4 7 12 N N ?
CL3,NBD1 p.Ser  434 * details homologous mutations 2 5 5 - - ?
CL3,NBD1 p.Leu  435 Val details homologous mutations 1 4 4 D N ?
CL3,NBD1 p.Leu  436 Phe details homologous mutations 1 1 1 N N ?
CL3,NBD1 p.Pro  439 Ser details homologous mutations 3 41 46 D D
CL3,NBD1 p.Leu  441 Pro details homologous mutations 5 42 51 D D
CL3,NBD1 p.Lys  442 * details homologous mutations 1 4 5 - - ?
CL3,NBD1 p.Asp  443 Tyr details homologous mutations 26 98 147 D D
CL3,NBD1 p.Ile  444 Ser details homologous mutations 2 3 3 D D
CL3,NBD1 p.Phe  446 Cys details homologous mutations 1 7 7 N D ?
CL3,NBD1 p.Lys  447 Arg details homologous mutations 1 8 10 N N ?
CL3,NBD1 p.Gly  451 Val details homologous mutations 1 4 4 D D ?
CL3,NBD1 p.Gly  451 Lys details homologous mutations 1 8 8 D D ?
CL3,NBD1 p.Gln  452 Pro details homologous mutations 3 7 7 D D
CL3,NBD1 p.Ala  455 Glu details homologous mutations 319 1068 1333 N D D
CL3,NBD1 p.Ala  455 Leu details homologous mutations 1 1 1 D D ?
CL3,NBD1 p.Ala  455 Val details homologous mutations 2 2 3 D D ?
CL3,NBD1 p.Val  456 Ala details homologous mutations 8 29 30 D D D
CL3,NBD1 p.Val  456 Phe details homologous mutations 6 22 24 N D
CL3,NBD1 p.Ala  457 Pro details homologous mutations 1 15 16 D N ?
CL3,NBD1,WA1 p.Gly  458 Val details homologous mutations 18 42 55 D D D
CL3,NBD1,WA1 p.Ser  459 Phe details homologous mutations 1 2 3 D D ?
CL3,NBD1,WA1 p.Ser  459 Arg details homologous mutations 1 1 1 D N ?
CL3,NBD1,WA1 p.Ser  459 Asn details homologous mutations 1 1 1 D N ?
CL3,NBD1,WA1 p.Ser  459 Cys details homologous mutations 1 7 7 D D ?
CL3,NBD1,WA1 p.Thr  460 Ser details homologous mutations 1 53 67 D N ?
CL3,NBD1,WA1 p.Ala  462 Phe details homologous mutations 6 26 27 D D ?
CL3,NBD1,WA1 p.Ala  462 Cys details homologous mutations 3 11 11 D N ?
CL3,NBD1,WA1 p.Gly  463 Asp details homologous mutations 2 3 3 D D ?
CL3,NBD1,WA1 p.Lys  464 Ala details homologous mutations 54 519 588 D D ?
CL3,NBD1,WA1 p.Lys  464 Met details homologous mutations 4 12 12 D D ?
CL3,NBD1,WA1 p.Lys  464 His details homologous mutations 3 28 30 D D ?
CL3,NBD1,WA1 p.Lys  464 Asn details homologous mutations 2 6 10 D D
CL3,NBD1,WA1 p.Lys  464 Leu details homologous mutations 2 12 12 D D ?
CL3,NBD1,WA1 p.Lys  464 Arg details homologous mutations 3 7 8 D D ?
CL3,NBD1,WA1 p.Lys  464 Trp details homologous mutations 1 2 2 D D ?
CL3,NBD1,WA1 p.Lys  464 Gln details homologous mutations 3 29 30 D D ?
CL3,NBD1,WA1 p.Thr  465 Asn details homologous mutations 2 11 16 D N ?
CL3,NBD1 p.Ser  466 Leu details homologous mutations 2 4 4 D D
CL3,NBD1 p.Ser  466 * details homologous mutations 19 65 76 - - D
CL3,NBD1 p.Ser  466 Thr details homologous mutations 1 3 4 D N ?
CL3,NBD1 p.Leu  467 Phe details homologous mutations 8 18 20 D D
CL3,NBD1 p.Leu  467 Pro details homologous mutations 9 16 19 D D D
CL3,NBD1 p.Met  469 Ile details homologous mutations 2 34 36 N N
CL3,NBD1 p.Met  469 Val details homologous mutations 3 12 14 N N
CL3,NBD1 p.Val  470 Met details homologous mutations 9 25 27 N N N
CL3,NBD1 p.Leu  475 Tyr details homologous mutations 1 3 5 N D ?
CL3,NBD1 p.Glu  479 * details homologous mutations 1 8 9 - -
CL3,NBD1 p.Gly  480 Cys details homologous mutations 46 221 244 N D D
CL3,NBD1 p.Gly  480 Ser details homologous mutations 1 4 5 D D
CL3,NBD1 p.Gly  480 Asp details homologous mutations 1 1 1 D D
CL3,NBD1 p.Lys  481 Glu details homologous mutations 1 2 2 D N ?
CL3,NBD1 p.His  484 Tyr details homologous mutations 2 3 3 D N
CL3,NBD1 p.His  484 Arg details homologous mutations 2 2 2 D N ?
CL3,NBD1 p.Ser  485 Cys details homologous mutations 4 10 10 N D
CL3,NBD1 p.Ser  485 Arg details homologous mutations 1 1 1 N N ?
CL3,NBD1 p.Arg  487 Gln details homologous mutations 1 2 2 D N ?
CL3,NBD1 p.Arg  487 Ala details homologous mutations 1 1 1 D N ?
CL3,NBD1 p.Arg  487 Ser details homologous mutations 1 2 2 D N ?
CL3,NBD1 p.Ser  489 * details homologous mutations 89 303 343 - - D
CL3,NBD1 p.Phe  490 Leu details homologous mutations 1 4 5 D D ?
CL3,NBD1 p.Cys  491 Ser details homologous mutations 9 56 68 N N ?
CL3,NBD1 p.Cys  491 Arg details homologous mutations 2 2 3 D N
CL3,NBD1 p.Cys  491 Ala details homologous mutations 1 19 24 N N ?
CL3,NBD1 p.Cys  491 Phe details homologous mutations 1 2 2 D N ?
CL3,NBD1 p.Cys  491 Val details homologous mutations 1 2 2 N N ?
CL3,NBD1 p.Ser  492 Phe details homologous mutations 27 40 44 D D D
CL3,NBD1 p.Ser  492 Pro details homologous mutations 6 28 39 D N ?
CL3,NBD1 p.Gln  493 * details homologous mutations 77 105 112 - - D
CL3,NBD1 p.Gln  493 Arg details homologous mutations 7 8 9 D D
CL3,NBD1 p.Gln  493 Ala details homologous mutations 2 18 20 D D D
CL3,NBD1 p.Gln  493 Pro details homologous mutations 1 4 4 D D
CL3,NBD1 p.Gln  493 Leu details homologous mutations 2 9 10 D D D
CL3,NBD1 p.Gln  493 His details homologous mutations 1 2 2 D D D
CL3,NBD1 p.Phe  494 Asn details homologous mutations 28 110 150 N N ?
CL3,NBD1 p.Phe  494 Gly details homologous mutations 1 2 2 N N ?
CL3,NBD1 p.Phe  494 Leu details homologous mutations 1 10 10 N N ?
CL3,NBD1 p.Ser  495 Tyr details homologous mutations 1 1 1 D D ?
CL3,NBD1 p.Ser  495 Pro details homologous mutations 2 9 9 N N ?
CL3,NBD1 p.Trp  496 * details homologous mutations 4 7 8 - -
CL3,NBD1 p.Trp  496 Phe details homologous mutations 2 6 6 D D ?
CL3,NBD1 p.Trp  496 Cys details homologous mutations 2 5 5 D D ?
CL3,NBD1 p.Trp  496 Val details homologous mutations 1 3 6 D D ?
CL3,NBD1 p.Met  498 Cys details homologous mutations 2 5 5 D D ?
CL3,NBD1 p.Pro  499 Ala details homologous mutations 3 20 23 D D
CL3,NBD1 p.Thr  501 Ile details homologous mutations 1 1 1 D D ?
CL3,NBD1 p.Thr  501 Ala details homologous mutations 2 5 5 D D
CL3,NBD1 p.Ile  502 Thr details homologous mutations 7 12 13 D D
CL3,NBD1 p.Glu  504 Gln details homologous mutations 4 11 11 N N
CL3,NBD1 p.Asn  505 Cys details homologous mutations 2 6 7 D D ?
CL3,NBD1 p.Asn  505 Ala details homologous mutations 1 3 3 D D ?
CL3,NBD1 p.Ile  506 Val details homologous mutations 34 61 67 N N N
CL3,NBD1 p.Ile  506 Thr details homologous mutations 15 20 20 D D
CL3,NBD1 p.Ile  506 Met details homologous mutations 6 7 8 D D
CL3,NBD1 p.Ile  506 Leu details homologous mutations 4 13 15 D N
CL3,NBD1 p.Ile  506 Cys details homologous mutations 1 1 1 D D ?
CL3,NBD1 p.Ile  506 Ser details homologous mutations 1 4 4 D D
CL3,NBD1 p.Ile  507 Val details homologous mutations 21 34 36 N N N
CL3,NBD1 p.Ile  507 Leu details homologous mutations 1 1 1 N N ?
CL3,NBD1 p.Ile  507 Thr details homologous mutations 1 1 1 D D ?
CL3,NBD1 p.Phe  508 Cys details homologous mutations 90 231 258 D D N
CL3,NBD1 p.Phe  508 Asp details homologous mutations 4 15 16 D D ?
CL3,NBD1 p.Phe  508 Ala details homologous mutations 16 69 71 D D ?
CL3,NBD1 p.Phe  508 Ser details homologous mutations 7 30 33 D D
CL3,NBD1 p.Phe  508 Arg details homologous mutations 11 38 41 D D ?
CL3,NBD1 p.Phe  508 Trp details homologous mutations 2 9 10 D D ?
CL3,NBD1 p.Phe  508 Met details homologous mutations 1 6 6 D D ?
CL3,NBD1 p.Phe  508 Pro details homologous mutations 2 8 8 D D ?
CL3,NBD1 p.Phe  508 Gln details homologous mutations 1 6 6 D D ?
CL3,NBD1 p.Phe  508 Gly details homologous mutations 2 3 3 D D ?
CL3,NBD1 p.Phe  508 Leu details homologous mutations 1 2 2 D D ?
CL3,NBD1 p.Phe  508 Asn details homologous mutations 2 7 9 D D ?
CL3,NBD1 p.Phe  508 Thr details homologous mutations 1 2 2 D D ?
CL3,NBD1 p.Phe  508 Val details homologous mutations 2 3 3 D D ?
CL3,NBD1 p.Phe  508 Glu details homologous mutations 2 3 3 D D ?
CL3,NBD1 p.Phe  508 His details homologous mutations 1 2 2 D D ?
CL3,NBD1 p.Phe  508 Ile details homologous mutations 2 4 4 D D ?
CL3,NBD1 p.Phe  508 Lys details homologous mutations 3 16 17 D D ?
CL3,NBD1 p.Phe  508 Tyr details homologous mutations 1 2 2 D D ?
CL3,NBD1 p.Phe  508 * details homologous mutations 3 4 4 - - ?
CL3,NBD1 p.Val  510 Ala details homologous mutations 21 98 123 N N ?
CL3,NBD1 p.Val  510 Cys details homologous mutations 13 34 36 N N ?
CL3,NBD1 p.Val  510 Asp details homologous mutations 29 217 256 N N ?
CL3,NBD1 p.Val  510 * details homologous mutations 1 3 3 - - ?
CL3,NBD1 p.Val  510 Pro details homologous mutations 1 1 1 N N ?
CL3,NBD1 p.Val  510 Thr details homologous mutations 2 3 3 N N ?
CL3,NBD1 p.Val  510 Gly details homologous mutations 2 5 5 N N ?
CL3,NBD1 p.Val  510 Ser details homologous mutations 1 2 2 N N ?
CL3,NBD1 p.Val  510 Glu details homologous mutations 1 4 4 N N ?
CL3,NBD1 p.Val  510 Arg details homologous mutations 2 9 9 N N ?
CL3,NBD1 p.Ser  511 Ala details homologous mutations 3 30 31 N N ?
CL3,NBD1 p.Ser  511 Asp details homologous mutations 3 25 30 N N ?
CL3,NBD1 p.Ser  511 Cys details homologous mutations 1 3 3 N D ?
CL3,NBD1 p.Tyr  512 Ala details homologous mutations 3 6 7 D D ?
CL3,NBD1 p.Tyr  512 Glu details homologous mutations 1 4 4 D D ?
CL3,NBD1 p.Tyr  512 Phe details homologous mutations 2 9 9 D N ?
CL3,NBD1 p.Tyr  512 Asp details homologous mutations 1 1 1 D D ?
CL3,NBD1 p.Tyr  515 His details homologous mutations 1 1 1 N N ?
CL3,NBD1 p.Arg  516 Lys details homologous mutations 8 19 19 N N ?
CL3,NBD1 p.Arg  516 Ala details homologous mutations 1 2 2 D D ?
CL3,NBD1 p.Tyr  517 Ala details homologous mutations 2 26 31 D D ?
CL3,NBD1 p.Tyr  517 Cys details homologous mutations 2 5 5 D D ?
CL3,NBD1 p.Tyr  517 Ile details homologous mutations 1 3 6 D D ?
CL3,NBD1 p.Arg  518 Ala details homologous mutations 1 1 1 N N ?
CL3,NBD1 p.Arg  518 Lys details homologous mutations 1 4 4 N N ?
CL3,NBD1 p.Ser  519 Gly details homologous mutations 1 3 3 N N ?
CL3,NBD1 p.Val  520 Phe details homologous mutations 95 149 160 D D D
CL3,NBD1 p.Val  520 Ile details homologous mutations 4 5 5 D N
CL3,NBD1 p.Ile  521 Phe details homologous mutations 2 2 2 D D ?
CL3,NBD1 p.Cys  524 * details homologous mutations 11 13 15 - - D
CL3,NBD1 p.Cys  524 Ser details homologous mutations 6 16 20 D D ?
CL3,NBD1 p.Cys  524 Ala details homologous mutations 1 3 6 D D ?
CL3,NBD1 p.Cys  524 Tyr details homologous mutations 1 2 3 D D ?
CL3,NBD1 p.Cys  524 Thr details homologous mutations 1 2 2 D D ?
CL3,NBD1 p.Gln  525 * details homologous mutations 5 6 6 - -
CL3,NBD1 p.Leu  526 Ala details homologous mutations 1 3 6 N D ?
CL3,NBD1 p.Glu  527 Gly details homologous mutations 4 8 9 D D ?
CL3,NBD1 p.Glu  527 Gln details homologous mutations 1 4 4 N N
CL3,NBD1 p.Glu  527 Asn details homologous mutations 1 6 6 N N ?
CL3,NBD1 p.Glu  528 Asp details homologous mutations 1 1 1 N N
CL3,NBD1 p.Glu  528 Gln details homologous mutations 1 3 4 N N ?
CL3,NBD1 p.Glu  528 * details homologous mutations 1 1 1 - - N
CL3,NBD1 p.Asp  529 Phe details homologous mutations 1 19 23 D D ?
CL3,NBD1 p.Asp  529 Asn details homologous mutations 1 6 10 D D ?
CL3,NBD1 p.Ile  530 Leu details homologous mutations 2 8 10 N N
CL3,NBD1 p.Ser  531 Pro details homologous mutations 2 13 22 N N ?
CL3,NBD1 p.Ser  531 Thr details homologous mutations 1 3 3 N N ?
CL3,NBD1 p.Lys  532 Glu details homologous mutations 1 1 1 N N ?
CL3,NBD1 p.Phe  533 Leu details homologous mutations 2 9 9 N N
CL3,NBD1 p.Ala  534 Glu details homologous mutations 3 4 4 N N D
CL3,NBD1 p.Ala  534 Pro details homologous mutations 5 15 24 N N ?
CL3,NBD1 p.Ala  534 Gln details homologous mutations 1 3 3 N N ?
CL3,NBD1 p.Lys  536 * details homologous mutations 4 12 12 - -
CL3,NBD1 p.Lys  536 Gln details homologous mutations 2 10 13 N N ?
CL3,NBD1 p.Asp  537 Asn details homologous mutations 1 5 5 D D ?
CL3,NBD1 p.Asp  537 Glu details homologous mutations 1 2 3 D D
CL3,NBD1 p.Asp  537 Phe details homologous mutations 1 3 4 D D ?
CL3,NBD1 p.Ile  539 Thr details homologous mutations 36 259 304 N N ?
CL3,NBD1 p.Leu  541 Pro details homologous mutations 3 15 18 D D ?
CL3,NBD1 p.Gly  542 * details homologous mutations 792 2752 3356 - - D
CL3,NBD1 p.Gly  542 Asp details homologous mutations 1 1 1 D D D
CL3,NBD1 p.Gly  542 Trp details homologous mutations 1 1 1 D D D
CL3,NBD1 p.Glu  543 Cys details homologous mutations 1 8 11 D D ?
CL3,NBD1 p.Glu  543 Ala details homologous mutations 3 19 19 D D ?
CL3,NBD1 p.Gly  544 Ser details homologous mutations 5 13 14 D N ?
CL3,NBD1 p.Gly  544 Val details homologous mutations 3 7 7 D D
CL3,NBD1 p.Thr  547 Cys details homologous mutations 1 5 5 D D ?
CL3,NBD1,SIG1 p.Leu  548 Gln details homologous mutations 2 5 7 D D ?
CL3,NBD1,SIG1 p.Leu  548 Cys details homologous mutations 1 3 3 D D ?
CL3,NBD1,SIG1 p.Ser  549 Arg details homologous mutations 143 384 463 N D D
CL3,NBD1,SIG1 p.Ser  549 Asn details homologous mutations 177 376 426 N D D
CL3,NBD1,SIG1 p.Ser  549 Ile details homologous mutations 24 31 35 D D D
CL3,NBD1,SIG1 p.Ser  549 Cys details homologous mutations 5 83 101 D D D
CL3,NBD1,SIG1 p.Ser  549 Lys details homologous mutations 1 1 1 D D D
CL3,NBD1,SIG1 p.Gly  550 Glu details homologous mutations 52 354 401 D D ?
CL3,NBD1,SIG1 p.Gly  550 His details homologous mutations 1 3 3 D D ?
CL3,NBD1,SIG1 p.Gly  550 Asp details homologous mutations 1 5 5 D D ?
CL3,NBD1,SIG1 p.Gly  550 Arg details homologous mutations 5 5 5 D D
CL3,NBD1,SIG1 p.Gly  550 * details homologous mutations 2 3 3 - -
CL3,NBD1,SIG1 p.Gly  551 Asp details homologous mutations 1116 6435 7514 D D D
CL3,NBD1,SIG1 p.Gly  551 Ser details homologous mutations 70 161 189 N D D
CL3,NBD1,SIG1 p.Gly  551 Ala details homologous mutations 4 23 23 D D D
CL3,NBD1,SIG1 p.Gly  551 Cys details homologous mutations 2 23 26 D D D
CL3,NBD1,SIG1 p.Gly  551 Arg details homologous mutations 2 2 2 D D D
CL3,NBD1,SIG1 p.Gly  551 * details homologous mutations 2 5 5 - - D
CL3,NBD1,SIG1 p.Gly  551 Glu details homologous mutations 2 6 6 D D D
CL3,NBD1,SIG1 p.Gly  551 Lys details homologous mutations 1 4 4 D D D
CL3,NBD1,SIG1 p.Gln  552 * details homologous mutations 67 93 101 - - D
CL3,NBD1,SIG1 p.Gln  552 His details homologous mutations 4 6 6 D D D
CL3,NBD1,SIG1 p.Gln  552 Ala details homologous mutations 3 6 6 D D D
CL3,NBD1,SIG1 p.Gln  552 Cys details homologous mutations 1 2 2 D D D
CL3,NBD1,SIG1 p.Arg  553 * details homologous mutations 538 1377 1612 - - D
CL3,NBD1,SIG1 p.Arg  553 Gln details homologous mutations 63 189 217 D N D
CL3,NBD1,SIG1 p.Arg  553 Gly details homologous mutations 13 21 23 D D
CL3,NBD1,SIG1 p.Arg  553 Met details homologous mutations 31 175 209 D D D
CL3,NBD1,SIG1 p.Arg  553 Lys details homologous mutations 3 3 3 D N D
CL3,NBD1,SIG1 p.Arg  553 Cys details homologous mutations 1 3 3 D D D
CL3,NBD1,SIG1 p.Arg  553 Asp details homologous mutations 1 1 1 D D D
CL3,NBD1,SIG1 p.Ala  554 Glu details homologous mutations 2 17 19 N N ?
CL3,NBD1,SIG1 p.Arg  555 Lys details homologous mutations 62 265 305 D D ?
CL3,NBD1,SIG1 p.Arg  555 Gln details homologous mutations 1 3 5 D D ?
CL3,NBD1,SIG1 p.Arg  555 Thr details homologous mutations 2 2 2 D D ?
CL3,NBD1,SIG1 p.Arg  555 Gly details homologous mutations 2 3 4 D D
CL3,NBD1,SIG1 p.Arg  555 Ala details homologous mutations 1 3 3 D D ?
CL3,NBD1,SIG1 p.Ile  556 Val details homologous mutations 20 92 143 N N
CL3,NBD1,SIG1 p.Leu  558 Ser details homologous mutations 28 40 43 D D D
CL3,NBD1,SIG1 p.Ala  559 Thr details homologous mutations 53 95 98 N D D
CL3,NBD1,SIG1 p.Ala  559 Glu details homologous mutations 2 3 3 D D
CL3,NBD1,SIG1 p.Arg  560 Thr details homologous mutations 222 431 471 D D D
CL3,NBD1,SIG1 p.Arg  560 Ser details homologous mutations 8 20 21 D D
CL3,NBD1,SIG1 p.Arg  560 Lys details homologous mutations 23 26 29 N D D
CL3,NBD1,SIG1 p.Arg  560 Cys details homologous mutations 1 1 1 D D ?
CL3,NBD1,SIG1 p.Arg  560 Gly details homologous mutations 3 3 3 D D
CL3,NBD1,SIG1 p.Ala  561 Glu details homologous mutations 20 160 203 N D D
CL3,NBD1,SIG1 p.Val  562 Leu details homologous mutations 6 18 18 N N
CL3,NBD1,SIG1 p.Val  562 Ile details homologous mutations 27 118 157 N N
CL3,NBD1,SIG1 p.Val  562 Ala details homologous mutations 1 1 1 D D ?
CL3,NBD1 p.Tyr  563 Asn details homologous mutations 23 49 64 D D D
CL3,NBD1 p.Tyr  563 Asp details homologous mutations 10 16 19 D D
CL3,NBD1 p.Tyr  563 Cys details homologous mutations 1 1 1 D D D
CL3,NBD1 p.Tyr  563 * details homologous mutations 2 4 4 - - D
CL3,NBD1 p.Tyr  563 Val details homologous mutations 1 3 6 D D D
CL3,NBD1 p.Tyr  563 His details homologous mutations 1 1 1 D D D
CL3,NBD1 p.Lys  564 Cys details homologous mutations 2 4 4 N N ?
CL3,NBD1 p.Asp  565 Gly details homologous mutations 16 77 92 D D
CL3,NBD1 p.Asp  565 Ala details homologous mutations 2 8 9 D D ?
CL3,NBD1 p.Ala  566 Thr details homologous mutations 1 7 8 N D
CL3,NBD1 p.Ala  566 Asp details homologous mutations 1 7 10 D D ?
CL3,NBD1 p.Ala  566 Pro details homologous mutations 1 3 4 D D ?
CL3,NBD1 p.Asp  567 Ala details homologous mutations 3 12 14 N D ?
CL3,NBD1,WB1 p.Leu  568 Phe details homologous mutations 4 8 9 D N
CL3,NBD1,WB1 p.Leu  568 * details homologous mutations 3 7 7 - -
CL3,NBD1,WB1 p.Tyr  569 Asp details homologous mutations 14 32 46 D D
CL3,NBD1,WB1 p.Tyr  569 Cys details homologous mutations 3 9 11 D D
CL3,NBD1,WB1 p.Tyr  569 * details homologous mutations 2 2 2 - -
CL3,NBD1,WB1 p.Tyr  569 His details homologous mutations 2 2 2 N D
CL3,NBD1,WB1 p.Leu  570 Asp details homologous mutations 1 3 3 D D ?
CL3,NBD1,WB1 p.Leu  571 Ser details homologous mutations 8 14 15 D D
CL3,NBD1,WB1 p.Leu  571 Asp details homologous mutations 1 3 3 D D ?
CL3,NBD1,WB1 p.Asp  572 Asn details homologous mutations 17 73 75 D D
CL3,NBD1,WB1 p.Asp  572 Met details homologous mutations 1 2 2 D D ?
CL3,NBD1,WB1 p.Asp  572 Ala details homologous mutations 2 6 7 D D ?
CL3,NBD1 p.Ser  573 Glu details homologous mutations 3 25 27 N N ?
CL3,NBD1 p.Ser  573 Cys details homologous mutations 3 47 53 D D ?
CL3,NBD1 p.Ser  573 Ala details homologous mutations 2 18 20 N N ?
CL3,NBD1 p.Pro  574 His details homologous mutations 92 409 511 D D D
CL3,NBD1 p.Pro  574 Ser details homologous mutations 3 44 59 D D
CL3,NBD1 p.Pro  574 Ala details homologous mutations 1 3 5 D D ?
CL3,NBD1 p.Phe  575 Tyr details homologous mutations 3 6 7 D N ?
CL3,NBD1 p.Phe  575 Thr details homologous mutations 1 3 4 N D ?
CL3,NBD1 p.Gly  576 Ala details homologous mutations 85 257 336 D N
CL3,NBD1 p.Gly  576 * details homologous mutations 3 3 3 - -
CL3,NBD1 p.Gly  576 Arg details homologous mutations 1 2 3 D N ?
CL3,NBD1 p.Tyr  577 Phe details homologous mutations 5 13 13 N N
CL3,NBD1 p.Tyr  577 His details homologous mutations 1 1 1 N N ?
CL3,NBD1 p.Tyr  577 Lys details homologous mutations 1 7 7 D N ?
CL3,NBD1 p.Tyr  577 Glu details homologous mutations 1 5 5 D N ?
CL3,NBD1 p.Asp  579 Gly details homologous mutations 26 54 63 D D
CL3,NBD1 p.Leu  581 Phe details homologous mutations 1 36 67 N N ?
CL3,NBD1 p.Thr  582 Ala details homologous mutations 3 16 17 N N ?
CL3,NBD1 p.Thr  582 Arg details homologous mutations 8 19 21 D D
CL3,NBD1 p.Thr  582 Ser details homologous mutations 1 1 1 N D
CL3,NBD1 p.Thr  582 Ile details homologous mutations 3 4 4 N N
CL3,NBD1 p.Glu  583 Gly details homologous mutations 1 4 5 N N ?
CL3,NBD1 p.Lys  584 Glu details homologous mutations 1 68 95 D N ?
CL3,NBD1 p.Glu  585 * details homologous mutations 46 83 85 - - D
CL3,NBD1 p.Glu  585 Gln details homologous mutations 1 4 4 N N D
CL3,NBD1 p.Ile  586 Val details homologous mutations 1 1 1 N N ?
CL3,NBD1 p.Phe  587 Ile details homologous mutations 2 2 2 N D ?
CL3,NBD1 p.Glu  588 Val details homologous mutations 3 19 26 D D
CL3,NBD1 p.Ser  589 Asn details homologous mutations 3 9 11 N N
CL3,NBD1 p.Ser  589 Ile details homologous mutations 3 11 12 N D
CL3,NBD1 p.Ser  589 Thr details homologous mutations