ABCG2 p.Tyr459Cys

Predicted by SNAP2: A: D (66%), C: D (59%), D: D (91%), E: D (75%), F: N (53%), G: D (75%), H: N (53%), I: D (63%), K: D (75%), L: D (66%), M: D (75%), N: D (63%), P: D (91%), Q: D (66%), R: D (59%), S: D (63%), T: D (66%), V: D (63%), W: D (75%),
Predicted by PROVEAN: A: D, C: D, D: D, E: D, F: D, G: D, H: N, I: D, K: D, L: D, M: D, N: D, P: D, Q: D, R: D, S: D, T: D, V: D, W: D,

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[hide] Zoernig I, Ziegelmeier C, Lahrmann B, Grabe N, Jager D, Halama N
Sequence mutations of the substrate binding pocket of stem cell factor and multidrug resistance protein ABCG2 in renal cell cancer: a possible link to treatment resistance.
Oncol Rep. 2013 May;29(5):1697-700. doi: 10.3892/or.2013.2324. Epub 2013 Mar 5., [PMID:23467750] [PubMed]

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[hide] Gal Z, Hegedus C, Szakacs G, Varadi A, Sarkadi B, Ozvegy-Laczka C
Mutations of the central tyrosines of putative cholesterol recognition amino acid consensus (CRAC) sequences modify folding, activity, and sterol-sensing of the human ABCG2 multidrug transporter.
Biochim Biophys Acta. 2015 Feb;1848(2):477-87. doi: 10.1016/j.bbamem.2014.11.006. Epub 2014 Nov 14., [PMID:25445676] [PubMed]

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