ABCG2 p.Cys608Gly

Predicted by SNAP2: A: D (71%), D: D (85%), E: D (85%), F: D (85%), G: D (85%), H: D (85%), I: D (71%), K: D (85%), L: D (85%), M: D (80%), N: D (85%), P: D (85%), Q: D (85%), R: D (85%), S: D (75%), T: D (80%), V: D (66%), W: D (91%), Y: D (80%),
Predicted by PROVEAN: A: D, D: D, E: D, F: D, G: D, H: D, I: D, K: D, L: D, M: D, N: D, P: D, Q: D, R: D, S: D, T: D, V: D, W: D, Y: D,

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[hide] Wakabayashi K, Tamura A, Saito H, Onishi Y, Ishikawa T
Human ABC transporter ABCG2 in xenobiotic protection and redox biology.
Drug Metab Rev. 2006;38(3):371-91., [PMID:16877258] [PubMed]

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[hide] Wakabayashi K, Nakagawa H, Tamura A, Koshiba S, Hoshijima K, Komada M, Ishikawa T
Intramolecular disulfide bond is a critical check point determining degradative fates of ATP-binding cassette (ABC) transporter ABCG2 protein.
J Biol Chem. 2007 Sep 21;282(38):27841-6. Epub 2007 Aug 8., 2007-09-21 [PMID:17686774] [PubMed]

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[hide] Koshiba S, An R, Saito H, Wakabayashi K, Tamura A, Ishikawa T
Human ABC transporters ABCG2 (BCRP) and ABCG4.
Xenobiotica. 2008 Jul;38(7-8):863-88., [PMID:18668433] [PubMed]

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[hide] Wakabayashi-Nakao K, Tamura A, Furukawa T, Nakagawa H, Ishikawa T
Quality control of human ABCG2 protein in the endoplasmic reticulum: ubiquitination and proteasomal degradation.
Adv Drug Deliv Rev. 2009 Jan 31;61(1):66-72. Epub 2008 Dec 11., 2009-01-31 [PMID:19111842] [PubMed]

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[hide] Ishikawa T, Nakagawa H
Human ABC transporter ABCG2 in cancer chemotherapy and pharmacogenomics.
J Exp Ther Oncol. 2009;8(1):5-24., [PMID:19827267] [PubMed]

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[hide] Ikebuchi Y, Ito K, Takada T, Anzai N, Kanai Y, Suzuki H
Receptor for activated C-kinase 1 regulates the cell surface expression and function of ATP binding cassette G2.
Drug Metab Dispos. 2010 Dec;38(12):2320-8. Epub 2010 Sep 21., [PMID:20858845] [PubMed]

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[hide] Nakagawa H, Toyoda Y, Wakabayashi-Nakao K, Tamaki H, Osumi M, Ishikawa T
Ubiquitin-mediated proteasomal degradation of ABC transporters: a new aspect of genetic polymorphisms and clinical impacts.
J Pharm Sci. 2011 Sep;100(9):3602-19. doi: 10.1002/jps.22615. Epub 2011 May 12., [PMID:21567408] [PubMed]

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[hide] Nikles D, Tampe R
Targeted degradation of ABC transporters in health and disease.
J Bioenerg Biomembr. 2007 Dec;39(5-6):489-97., [PMID:17972020] [PubMed]

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